The first explosion happened on a bus near the campus of the Sardar Bahadur Khan Women's University, with a bomb hidden in the vehicle, reports said.
The second blast struck the casualty ward of the Bolan Medical Complex, and firing continued in the aftermath. At least eight unidentified gunmen were reported to have taken positions in the hospital, and killed at least four security personnel who were attempting to resecure the facility and three nurses, local officials said.
Chaudhry Nisar Ali Khan, the country's interior minister, said that the siege had ended by 8:30pm local time (15:30 GMT) on Saturday, with security forces freeing 35 people trapped inside the building and killing four of the attackers. One of the attackers was also arrested.
Khan confirmed that four security forces personnel and one senior government official had been killed during the violence.
Zubair Mahmood, the city police chief, described the bombing targetting the bus earlier in the day as having been carried out by an "improvied explosive device". The bomb exploded after the students had boarded and the bus was leaving the university.
Another police official, Fayyaz Sumbal, added that the bus caught fire after the explosion and many students were critically wounded.
"As casualties were being brought to the hospital terrorists had taken position inside the hospital building," Khan told reporters. "They opened fire on on administration and police officials who arrived at the hospital.One suicide bomber blew himself up in the hospital."
Siege at hospital
Authorities say that Abdul Mansoor Khan, the deputy commissioner of Quetta, was among those killed at the hospital, Al Jazeera's Kamal Hyder reported. So far, at least 36 people have been injured in both attacks, he said.
Pakistani security forces surrounded the hospital and carried out an operation to clear it once the gunmen had taken over.
Quetta is the capital city of Balochistan province, and regularly witnesses violence on a large scale.
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